P-Shot in London: Procedure, Evidence and Risks
- Fabio Castiglione
- May 6, 2023
- 4 min read
Updated: 6 days ago
A P-Shot is a commercial name for platelet-rich plasma (PRP) injected into penile tissue. PRP is prepared from the patient’s own blood. It is offered by some private clinics for erectile dysfunction or sexual-health concerns, but current European guidance considers the evidence insufficient for routine treatment and advises use in a clinical-trial setting.
A P-Shot consultation should begin with a diagnosis. It should not be presented as a universal, approved or reliably effective solution for erectile dysfunction.
What is a P-Shot?
The term P-Shot usually describes an intracavernosal PRP procedure. A small blood sample is processed in a centrifuge to separate plasma with a higher platelet concentration. After local anaesthetic, the prepared PRP is injected into selected areas of the erectile tissue.
PRP contains platelets and signalling proteins involved in normal tissue responses. This biological rationale is why PRP has been studied in many medical fields. A plausible mechanism, however, is not the same as proven clinical benefit for erectile dysfunction.
What happens during the procedure?
Assessment: medical and sexual history, current medicines, cardiovascular risk and previous ED treatments are reviewed.
Blood collection: a sample is taken from a vein in the arm.
Preparation: the sample is centrifuged using the clinic’s PRP system.
Anaesthetic and injection: local anaesthetic is used before PRP is injected into erectile tissue.
Aftercare: the clinician explains activity, hygiene, pain relief, warning signs and whether a vacuum erection device is appropriate.
Preparation systems, platelet concentration, injection sites and treatment schedules vary. Patients should ask exactly what is being used and why, because there is no universally validated P-Shot protocol.
Does PRP improve erectile dysfunction?
Small trials have reported changes in erectile-function scores, but the studies use different PRP products, doses and follow-up periods. Sample sizes are limited, and the ideal patient group, number of injections and duration of any benefit are uncertain.
The European Association of Urology states that evidence is insufficient to recommend PRP for routine ED treatment and advises its use only in a clinical-trial setting. This differs from established options such as risk-factor treatment, PDE5 inhibitor tablets, psychosexual therapy, vacuum devices, injection therapy and penile prosthesis surgery.
Read the full guide to erectile dysfunction assessment and treatment in London.
What are the possible risks?
Using the patient’s own blood may reduce the risk of an allergic reaction to the injected material, but it does not make the procedure risk-free.
Pain or discomfort during or after the injection.
Bruising, swelling or bleeding.
Infection, although sterile technique aims to reduce this risk.
Temporary changes in sensation.
Anxiety, vasovagal symptoms or distress related to blood collection and penile injection.
No meaningful improvement despite the financial and procedural burden.
A responsible consent discussion should also cover who will manage an adverse effect, what follow-up is included and what happens if symptoms do not improve.
Who should be cautious or seek further assessment first?
Men taking anticoagulants or with a bleeding disorder.
Anyone with active genital infection, skin inflammation or an unexplained penile lesion.
Men with unstable cardiovascular symptoms or ED that has not been medically assessed.
Patients with severe penile curvature, pain or a palpable plaque that may indicate Peyronie’s disease.
Anyone expecting permanent enlargement or a certain result.
Individual suitability depends on diagnosis, medicines, examination and goals. A fixed package should not be recommended solely from an online enquiry.
P-Shot, shockwave therapy and P-Shocks: what is the difference?
The P-Shot is PRP injection. Low-intensity shockwave therapy uses acoustic pulses and has a weak guideline recommendation for selected men with vasculogenic ED. P-Shocks is the clinic’s name for a broader pathway that may combine assessment, shockwave, PRP, a vacuum device and established treatments.
There is no reliable evidence that combining PRP with shockwave therapy creates an additional synergistic benefit. Each component should be justified separately.
See the direct comparison: P-Shocks vs P-Shot—evidence, differences and risks.
Review the evidence for shockwave therapy for erectile dysfunction.
What should a London P-Shot consultation include?
A clear diagnosis and assessment of vascular, metabolic, hormonal, medication-related and psychological contributors.
Discussion of established first-line and second-line ED treatments.
An honest explanation that PRP remains investigational for ED.
The exact preparation system, injection plan and person performing the procedure.
Risks, alternatives, total price, aftercare and follow-up.
No claims of a certain outcome, permanent enlargement or a fixed duration of benefit.
Frequently asked questions
Is the P-Shot an approved treatment for ED?
The P-Shot is a commercial procedure name, not a standard guideline-recommended ED treatment. PRP evidence remains insufficient for routine use, and patients should be told that it is investigational.
How quickly does it work?
There is no dependable timetable. Studies use different protocols and measure outcomes at different intervals. Some patients report change, while others do not experience meaningful benefit.
How long do results last?
A reliable duration has not been established. Claims of a fixed number of months are not supported well enough to apply to every patient.
Does the P-Shot increase penis size?
Reliable permanent length or girth enlargement has not been established. Improved erection firmness can change perceived size, but that is different from anatomical enlargement.
Can PRP treat Peyronie’s disease?
Evidence is preliminary and does not establish reliable improvement in curvature or plaque. Men with deformity should have a Peyronie’s-specific assessment.
Read about non-surgical options for Peyronie’s disease.
P-Shot assessment at 9 Harley Street, London
Dr Fabio Castiglione provides confidential assessment for erectile dysfunction and Peyronie’s disease at Holistic Andrology, 9 Harley Street, London W1G 9QY. The consultation reviews established options first and explains clearly where PRP sits within current evidence.
For clinic information or to request an assessment, visit P-Shocks London.
Medical review and evidence
Medically reviewed by Dr Fabio Castiglione, Consultant Urologist and Andrologist. Last reviewed: 19 August 2026.
Current EAU guidance considers the evidence for PRP in erectile dysfunction insufficient for routine clinical use and advises PRP only in a clinical-trial setting.
This article is for general education and is not a diagnosis or individual medical recommendation. A consultation should review medical and sexual history, current medicines, examination findings and tests when clinically indicated.
Clinical sources
European Association of Urology: Management of Erectile Dysfunction
About the author
Dr Fabio Castiglione
Consultant Urologist and Andrologist in London. Holistic Andrology, 9 Harley Street, London W1G 9QY.
GMC reference number: 7541824
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