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  • Writer's pictureFabio Castiglione

Non-surgical treatments for Peyronie's disease

What is Peyronie’s disease?

Peyronie's disease is a condition that affects the penis and causes it to bend or curve abnormally during erections. It is named after François Gigot de la Peyronie, a French surgeon who first described the condition in the 18th century.

What are Peyronie’s disease's symptoms?

Peyronie's disease can cause significant physical and emotional distress for men, as it can affect their ability to have normal sexual intercourse. It is thought to affect around 5-9% of men, although the actual number may be higher due to many men not seeking medical help for the condition.

The exact cause of Peyronie's disease is not fully understood, but it is thought to be the result of scar tissue forming inside the penis. This scar tissue, known as plaque, can cause the penis to curve or bend when it becomes erect. The plaque is usually located on the top or bottom of the penis and can be felt as a hard lump under the skin.

Peyronie's disease can develop slowly over time, with symptoms often appearing gradually. Some men may not notice any symptoms until the curve in their penis becomes severe. Other men may experience pain and discomfort during erections, difficulty achieving or maintaining an erection, and reduced sexual satisfaction.

Risk factors for developing Peyronie's disease

There are several potential risk factors for developing Peyronie's disease, including:

  • Age: Peyronie's disease is more common in men over the age of 40

  • Trauma to the penis: Previous injury or surgery on the penis may increase the risk of Peyronie's disease

  • Connective tissue disorders: Men with certain connective tissue disorders, such as Dupuytren's contracture or Ledderhose disease, may be more likely to develop Peyronie's disease

  • Family history: There may be a genetic component to Peyronie's disease, as it is more common in men who have a family history of the condition

Diagnosis of Peyronie's disease is usually based on a physical examination and a review of the patient's medical history. In some cases, additional testing may be needed to confirm the diagnosis, such as an ultrasound or MRI.

Treatment for Peyronie's disease may include medications, physical therapy, or surgery. The choice of treatment will depend on the severity of the condition and the degree of curvature in the penis.

Medications for Peyronie's disease

Medications for Peyronie's disease may include medications that are injected directly into the plaque to help soften and break down the scar tissue. Physical therapy may involve stretching and massaging the penis to help improve its flexibility and straighten the curve.

Surgeries for Peyronie's disease

Surgery is generally reserved for more severe cases of Peyronie's disease or for men who do not respond to other forms of treatment. There are several different surgical options available, including:

  • Penile plication: This procedure involves suturing the sides of the penis together to straighten the curve.

  • Penile implants: Penile implants, also known as penile prostheses, can be used to help straighten the penis and improve sexual function.

  • Penile straightening procedures: These procedures involve cutting and repositioning the tissue in the penis to straighten the curve.

Recovery from Peyronie's disease treatment can vary depending on the type of treatment received. Men who have surgery may need to take time off work to recover, and sexual activity may need to be avoided for a period of time following treatment.

Non-surgical treatments for Peyronie's disease

P-Shocks® is the most advanced treatment for Peyronie’s disease and erectile dysfunction in London. The evolution of Pshot, P-Shocks®, was created by the stem cell scientist Dr Fabio Castiglione director and founder of Holistic Andrology.

-Shocks® is an advanced regenerative therapy protocol for erectile dysfunction or Peyronie’s disease. It involvesa combination of shock wave sessions, medications, supplements, vacuum pump therapy, and platelet plasma (PRP).The P-Shocks® is tailored to each patient based on their level of impotence or penile deformity

P-shot London

Dr Castiglione's protocol for Peyronie's disease consists of five main components: reduction of fibrosis through the activation of nitric oxide, remodeling of the scar with the penile pump, micro-needling of the penile plaque, platelet rich plasma (PRP) injection into the plaque, and nitric oxide antifibrotic effect. Nitric oxide is a gas and neurotransmitter with important functions for our health and body, such as vasodilation and modulation of the immune system. It is the basis of an erection and causes the smooth muscle cells of the penis, present in the corpus cavernosum, to relax, thus causing an erection. Dr Castiglione's protocol involves increasing nitric oxide production, reducing fibrosis, using shock waves to break up scar tissue, and using platelet-rich plasma to remodel the fibrotic plaque. Microneedling is used to break up old scar tissue and stimulate the production of fresh collagen and elastin.

The penile pump is a tube in which a vacuum is induced which allows blood to enter the penis and stimulate an erection. The aim is to allow the plaque to relax completely.


Peyronie's disease can be a challenging condition to live with, but with proper treatment and support, it is possible to manage the symptoms and improve sexual function. If you are experiencing symptoms of Peyronie's

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