PRP for Peyronie’s Disease: Current Evidence and Risks
Updated: Aug 19
Platelet-rich plasma (PRP) is being studied for Peyronie’s disease, but current evidence is preliminary. Published studies are small and do not establish reliable improvement in penile curvature, plaque, length or erectile function. PRP should therefore be described as investigational rather than routine treatment.
A biological theory and early study results are not enough to promise that PRP can dissolve plaque, regenerate penile tissue or straighten the penis.
Why is PRP being studied for Peyronie’s disease?
PRP is prepared from a patient’s blood and contains platelets plus signalling proteins involved in normal clotting and tissue responses. Researchers have explored whether these components might influence inflammation or scar remodelling. That hypothesis requires clinical proof using meaningful outcomes such as measured curvature, intercourse function and patient-reported benefit.
How is PRP prepared and administered?
A blood sample is taken from a vein.
The sample is centrifuged to separate a platelet-rich plasma fraction.
Local anaesthetic may be used.
PRP is injected into penile tissue or plaque according to the clinic’s protocol.
Aftercare and warning signs are explained, with follow-up to assess symptoms and deformity.
PRP systems differ in platelet concentration, white-cell content, activation, volume and injection technique. Because there is no validated standard protocol for Peyronie’s disease, two treatments marketed with the same name may not be equivalent.
What do clinical studies show?
Small studies and early trials have reported changes in pain, plaque characteristics, curvature or erectile-function scores. However, limitations include small samples, differing protocols, short follow-up, variable outcome measurement and a lack of strong independent replication.
The available evidence does not show how PRP compares with observation, traction, intralesional treatment or surgery for clearly defined patient groups. It also does not establish an ideal dose, number of injections or durable benefit.
What do guidelines say?
Current European guidance does not recommend PRP as routine treatment for Peyronie’s disease. Management is organised around disease phase, pain, deformity, intercourse function, erectile function and patient goals. Any use of PRP should be accompanied by a clear explanation of uncertainty and established alternatives.
Read the full guide to non-surgical Peyronie’s disease treatment in London.
Possible risks and limitations
Pain or discomfort from blood collection and penile injection.
Bruising, swelling or bleeding.
Infection despite sterile precautions.
Temporary change in sensation or increased anxiety.
No meaningful change in curvature, plaque or erections.
Financial cost and delay in moving to an established option.
Autologous treatment means the PRP comes from the patient, but it does not mean the procedure is risk-free or certain to help.
Can PRP straighten penile curvature?
Reliable straightening has not been established. Clinics should not promise a specific degree of curvature reduction, plaque dissolution or restoration of lost length. Objective photographs or measurements are important when evaluating any claimed change.
PRP compared with shockwave therapy
PRP involves an injection. Shockwave therapy uses acoustic pulses. For Peyronie’s disease, shockwave may be considered for pain in selected patients but is not recommended to correct curvature or reduce plaque. Neither treatment has strong evidence for straightening.
PRP as part of P-Shocks
P-Shocks is the clinic’s name for a care pathway that may combine assessment, PRP, shockwave therapy, a vacuum device and established treatment. There is no reliable evidence that the combination creates a synergistic anti-scar effect. Each component should be justified separately.
Compare the components in P-Shocks vs P-Shot—evidence, differences and risks.
Established and guideline-based alternatives
Observation when symptoms are mild and intercourse remains possible.
Penile traction for selected patients who can follow a structured protocol.
Treatment for associated erectile dysfunction.
Intralesional treatment for suitable deformities where available.
Surgery for stable deformity that prevents satisfactory intercourse.
The right alternative depends on active versus stable disease, curvature, indentation or hourglass deformity, length, erection quality and priorities.
Questions to ask a clinic offering PRP
What evidence supports PRP for my specific disease phase and deformity?
Is the treatment part of a registered clinical study?
How will curvature and patient-reported outcomes be measured?
Which PRP preparation system and injection protocol are used?
What are the risks, alternatives, total cost and follow-up arrangements?
What happens if PRP does not help or the deformity progresses?
Frequently asked questions
Is PRP a cure for Peyronie’s disease?
No. Current evidence does not establish PRP as a cure or routine treatment.
How many injections are needed?
There is no universally validated number. A fixed package should not be treated as proof of an effective protocol.
Is PRP safer than surgery?
PRP is less invasive than surgery, but the comparison is incomplete because surgery and PRP have different indications and very different levels of evidence. A less invasive procedure is not automatically more appropriate.
Can PRP restore lost penile length?
Reliable restoration of lost length has not been established. Traction may be discussed for length preservation or modest improvement in selected patients.
Should PRP be used during the active phase?
There is insufficient evidence to define an ideal disease phase for PRP. Treatment should not be chosen without assessing whether pain or deformity is still changing.
PRP and Peyronie’s assessment in London
Dr Fabio Castiglione assesses Peyronie’s disease and erectile dysfunction at Holistic Andrology, 9 Harley Street, London W1G 9QY. The consultation documents disease phase and deformity, discusses guideline-based care and explains the investigational status of PRP.
For clinic information or to request an assessment, visit P-Shocks London.
Medical review and evidence
Medically reviewed by Dr Fabio Castiglione, Consultant Urologist and Andrologist. Last reviewed: 19 August 2026.
Evidence for PRP in Peyronie’s disease remains preliminary and does not establish reliable improvement in curvature or plaque. Treatment choice should be based on disease phase, deformity, erectile function and patient goals.
This article is for general education and is not a diagnosis or individual medical recommendation. A consultation should review medical and sexual history, current medicines, examination findings and tests when clinically indicated.
Clinical sources
European Association of Urology: Penile Curvature and Peyronie’s Disease
European Association of Urology: Management of Erectile Dysfunction
About the author
Dr Fabio Castiglione
Consultant Urologist and Andrologist in London. Holistic Andrology, 9 Harley Street, London W1G 9QY.
GMC reference number: 7541824
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